Lymphomatoid papulosis is one of two primary cutaneous CD30 positive cutaneous lymphomas, according to the WHO / EORTC classification.
Histology lymphomatoid papulosis
Scanning power of pathology of lymphomatoid papulosis reveals a wedge shape inflammatory infiltrate stretching deep dermis or superficial subcutaneous tissue (Figures 1 and 2). Please note that it is made of prominent telangiectatic vessels and extravasation of erythrocytes in the case illustrated here (Figures 3 and 4). the lymphocytic the population is made up of a series of large CD30-positives lymphocytes (Figure 5). The mixture of cells forms a spectrum.
Type A: scattered or grouped large positive CD30 lymphocytes (Figure 6) in a context of eosinophils and neutrophils.
Type B: A population of small lymphocytes can be seen with epidermotropism. This type may resemble mycosis fungoides.
Type C: large leaves anaplastic cells with only a few mixed inflammatory cells that resemble anaplastic large cells lymphoma.
Type D: marked epidermotropism is observed histologically indistinguishable from CD8 + primary aggressive cutaneous epidermotropic cytotoxic T cell lymphoma
Pathology of lymphomatoid papulosis.
Figure 1
Figure 2
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Figure 5
Figure 6
Special spots in lymphomatoid papulosis.
A panel of immunoperoxidase markers is used, the key finding is CD30 positivity in types A and C. Typically tumor cells are CD4 +, but CD8 + and CD56 + variants have been described. TIA-1, perforin, and granzyme-B are expressed while ALK-1 is negative.
The expression of fascinates may indicate an increased risk of secondary malignancies.
Differential diagnosis lymphomatoid papulosis
Primary cutaneous anaplastic cutaneous lymphoma: This tumor presents clinically in differential form as a large solitary ulcerated tumor. Strictly by definition, the> 75% of tumor cells must stain CD30 positive. A great nodular and a cohesive population of large anaplastic cells is observed.
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