Eccrine carcinoma pathology

Eccrine carcinoma it's a weirdo tumor which usually presents as slow growth plates or nodules on the scalp but can arise in other places.

Histology of eccrine carcinoma

Sections of eccrine carcinoma show a tumor composed of basaloid cells infiltrating the dermis (Figure 1). The tumor forms tubules and glands (figures 2-4) that infiltrate a sclerotic dermis. Eccrine differentiation it is easily seen at high power (best seen in figures 2 and 3). A clear cellular change can be seen (figure 4).

Special studies for eccrine carcinoma.

Immunohistochemical studies can be used to demonstrate glandular differentiation (CEA) in eccrine carcinoma, but are not necessary if the morphology It's classic. Some cases resemble breasts Cancer. Focal The positivity of p63 and CK5/6 is believed to favor a primary eccrine carcinoma.

Differential diagnosis of eccrine carcinoma

Metastatic Breast cancer: Clinical correlation may be necessary to distinguish primary eccrine carcinoma from metastatic breast carcinoma. Immunohistochemical studies (see above) may be useful

Microcystic attached Carcinoma (MAC): Some authors consider eccrine carcinoma to be a form of MAC. MAC usually demonstrates some scaly differentiation and keratinization cystic changes superficially.

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