Eccrine Spiradenocarcinoma Pathology

Introduction

Eccrine spiradenocarcinoma is a rare sweat gland tumor. It usually arises within a preexisting eccrine spiradenoma that has been present for many years.

Histology eccrine spiradenocarcinoma

In eccrine spiradenocarcinoma, sections show areas of benign Eccrine spiradenoma with an abrupt transition in morphology (Figures 1, 2). the evil one The areas may be carcinomatous or sarcomatous. the carcinoma usually shown marked nuclear pleomorphism, atypia and mitosis (Figures 2, 3).

A low-grade form has also been described in which the tumor cells show less nuclear atypia, but the usual architecture of eccrine spiradenoma is lost, mitoses are increased, and often infiltration of the surrounding structures.

Special studies of eccrine spiradenocarcinoma.

Generally none is needed. Stains to examine lymphatic (D2-40) or the proliferative rate (ki67) can be useful.

Differential diagnosis eccrine spiradenocarcinoma

Metaplastic changes within a benign eccrine spiradenoma. Scaly metaplasia it is not uncommon in benign lesions, but usually shows minimal nuclear atypia.