Pathology of Flegel's disease

Flegel's disease is rare skin disease characterized by asymptomatic hyperkeratotic papules predominantly on the back of the feet and legs. Clinical input is often very helpful in making a diagnosis. histopathologically. The disorder is believed to be caused by disturbances in the lining of the membrane. granules (lamellar granules, bodies of Odland) of the keratinocytes

Histology of hyperkeratosis lenticularis perstans (Flegel's disease)

In Flegel's disease, sections show discreet areas of compact lamellar hyperkeratosis with focal parakeratosis (Figure 1). the epidermis underneath hyperkeratosis is atrophic compared to the surrounding skin, and the granular layer it is dimmed absent (figure 2). The papillary dermis contains a dense band infiltrate composed of small lymphocytes interspersed with histiocytes. Vasodilation Superficial vessels are also seen (Figure 3).

Special studies for lenticular hyperkeratosis perstans (Flegel's disease)

Generally none is needed. Examination of membrane coating granules by electon microscopy It is commonly reported in the literature, but is not considered useful for diagnosis.

Differential diagnosis of lenticular hyperkeratosis perstans (Flegel's disease) pathology

Kyrle's disease: This condition is clinically similar and may share some pathogen components. Kyrle's disease should exhibit impressive curb plug and inflammatory perforating material through the epidermis.

Porokeratosis Cornoids the blades allow easy diagnosis of this condition

Actinic keratosis - actinic dysplasia is seen. Some authors believe that Flegel's disease is an incipient form epidermal dysplasia