Cytomegalovirus infection pathology

Histology cytomegalovirus infection

Cytomegalovirus (CMV) is a member of the family Herpesviridae. In cutaneous cytomegalovirus infection, markedly enlarged endothelial Cells lining small vessels are seen (Figure 1, arrows). These are bigger and eosinophilic compared to normal or reactive endothelial cells. The hallmark histologic feature is a large intranuclear inclusion that is densely eosinophilic (Figure 2, arrow). Other cells like fibroblasts and epithelial Cells are less involved.

the inclusions can be seen in the context of the overlay epidermal ulceration and others not specific inflammatory changes Leukocytoclastic vasculitis it is a described reaction pattern.

Special studies for cytomegalovirus infection.

Immunohistochemical studies against CMV are a very specific way to confirm the presence of the virus (Figure 3). PCR can also be used.

Differential diagnosis of cytomegalovirus infection pathology

Reactive changes: Reactive endothelial cells can become enlarged and hyperchromatic. Dense eosinophilia (Figure 1) and classic intranuclear inclusions (Figure 2) are not considered a reactive phenomenon. Immunohistochemistry It can be useful if necessary (Figure 3).