Corral smallpox pathology

Introduction

The virus of the genus Parapoxvirus is transmitted to humans from infected sheep or goats (orf), cows (milkers nodule) and oral mucous membrane cattle papular stomatitis)

Histology farmyard pox

Biopsy of a fully developed classical farmyard chicken pox papulovesicle exhibits a intraepidermal blister secondary to massive balloon of infected keratocytes and posterior necrosis (Figure 1). Necrosis and acute spongiosis they often accompany the balloon (figure 2). The intranuclear inclusions They are eosinophilic and it can be extremely difficult to find (figure 3, arrow). Often the reaction pattern, necrosis, and ballooning. keratinocytes degeneration is the only clue and a clinical history of exposure to farm animals together with complementary studies can lead to the correct diagnosis.

Special stains for farmyard pox

The inclusion bodies of smallpox can be highlighted by Lendrum's phloxine tartazine.

Culturefluorescent antibody test and electron microscopy It can be used to demonstrate the causative smallpox virus.

Differential diagnosis farmyard pox pathology

Cow pox, horse pox, and smallpox: They also exhibit impressive swelling of keratocytes, necrosis, and inclusion bodies that may resemble those seen in chickenpox. A medical history and, if necessary, ancillary microbiological investigations may be necessary for an accurate diagnosis.

Herpes simplex, chickenpox, and zoster: Viral inclusions are very different.