Xanthoma eruptive pathology

Introduction

Eruptive xanthoma occurs as rose cultures papules which are often pruritus. It occurs as a result of high concentrations of plasma triglycerides. Many patients have uncontrolled diabetes. Xanthomas usually go away when the underlying condition is treated.

Histology of eruptive xanthoma

In eruptive xanthoma, the dermis contains a dense population of foam histiocytes (histiocytes filled with lipid material as well as extracellular lipid (Figures 1-3). There is often an associate acute and chronic inflammatory answer (figure 4).

Special studies for eruptive xanthoma

Generally none is needed. Special spots to highlight lipids. statement they have been described but are rarely needed.

Differential diagnosis for eruptive xanthoma

There is a wide range of conditions that result in the accumulation of foamy histiocytes in the dermis and can simulate eruptive xanthoma. The correct diagnosis is generally confirmed by correlating the characteristics of the biopsy with the clinical presentation and serological findings.

Other xanthomatous conditions include:

• Infection - the pathology Leprosy may show a buildup of foamy histiocytes in the dermis. Special stains for the deceased. organisms (Mycobacterium leprae) can be useful in difficult cases
• Other xanthomas: These are generally easily excluded with clinical presentation. It is unusual in other forms of xanthoma to see the degree of extracellular lipids and the acute inflammatory response observed in the eruptive xanthoma.

• Xanthogranuloma: these generally show a mixture of inflammatory cells and characteristically show Touton giant cells.