Calciphylaxis is seen almost exclusively in patients with end-stage kidney disease. Calcification of glasses and Soft fabric cause skin heart attack and subsequent necrosis.
Histology calciphylaxis
A deep biopsy to test the subcutis It is necessary to make the diagnosis of calciphylaxis. the epidermis and dermis often ulcerates and necrotic with numerous secondary changes (figure 1). There is calcification of small and medium vessels (Figures 2-3). The intima of the vessels is usually fibrous and there may be intravascular thrombi Diffuse small calcification capillaries in fat it is a characteristic trait (figure 3). There may also be calcification of adipocytes.
Calciphylaxis pathology
Figure 1
Figure 2
figure 3
Special studies of calciphylaxis.
Calcium can be demonstrated with special stains such as Von Kossa.
Differential diagnosis calciphylaxis
A medical history of renal Failure and necrotic skin lesions can be helpful in providing confidence in the diagnosis of calciphylaxis.
Vascular calcification: may be associated with atherosclerosis and diabetes Vascular thrombosis and calcification of numerous capillaries / fats suggest calciphylaxis.
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