Churg-Strauss syndrome pathology

Introduction

Eosinophilic granulomatosis with polyangiitis also known as Churg-Strauss syndrome and Allergic granulomatosis It is a autoimmune illness that begins with allergic symptoms (asthma / hay) fever-as symptoms) and evolves to a vasculitis with associated tissue damage. Skin involvement occurs in approximately half of patients and presents as purple, petechiae, cutaneous nodulesand papules.

Histology of eosinophilic granulomatosis with polyangiitis

In eosinophilic granulomatosis with polyangiitis, the histopathology varies depending on the stage of the disease and the type of injury biopsy Usually presentation on the skin occurs in the later stages of the disease and prominent features include tissue eosinophilia (often with eosinophils statement 'figures of flames' in collagen fibers) and extravascular granulomas (Figures 1–3). Posterior lesions characteristically show vasculitis, involving small to medium vessels in the dermis and subcutis.

Special studies for eosinophilic granulomatosis with polyangiitis

Generally none is needed.

the differential diagnosis for eosinophilic granulomatosis with polyangiitis

Other forms of vasculitis generally do not show extravascular granulomas and the prominent tissue eosinophilia seen in eosinophilic granulomatosis with polyangiitis. Correlation with clinical and serological The findings are often essential to rule out other forms of vasculitis.