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Glomus tumor pathology

Glomus tumors are painful. They arise from the neuromyoarterial glomus cells found in the fingers and palms. The normal counterpart from which these tumors arise is the Suquet-Hoyer canal. The clinic injury It is a 1-2 cm reddish-blue solitaire papule in a young adult

Histology of glomus tumors

Glomus tumors are dermal, good circumscribed and consist of small vessels surrounded by glomus cells (Figure 1). Glomus cells have a soft round to oval shape nucleipale eosinophilic cytoplasm and clearly defined cell margins (Figure 2, 3, 4). Mitotic figures and pleomorphism It should not be prominent.

Glomus tumor pathology

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Figure 1

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Figure 2

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figure 3

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Figure 4

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Figure 5

Special studies of glomus tumors.

Glomus cells are positive for SMA and muscle-specific actin. Myosin can be positive. CD34 and CD31 are positive in endothelial cells; glomus cells are generally negative (Figure 5, CD31 staining).

Differential diagnosis of glomus tumors

Glomuvenous malformation (glomangioma): Vascular The component is more prominent and with dilated vessels. Thrombosis and phlebolith formation may be evident.

Eccrine spiradenoma: distinguished by the presence of two cell populations, positivity for epithelial bookmarks and focal ductal differentiation.

Intradermal nevus: Glomus cells can sometimes resemble naevomelanocytes. Naevus cells are positive with S100 and Melan-A