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Flegel's disease

What is Flegel's disease?

Flegel's disease is also known as hyperkeratosis lenticularis perstans. It was first described by Flegel in 1958. It is characterized by a red-brown color. papules with irregular horny scales located mainly on the upper surface of the feet and legs. It is very similar to Kyrle's disease and has been considered as a variant of Kyrle's disease, however, its clinical and pathological picture is different enough to make it its own disease entity.

What causes Flegel's disease?

The cause of the disease is unknown. It is believed to be an inherited condition, although cases have been reported where there is no family history of the disease. Sun exposure has also been implicated but not proven.

Flegel's disease has been reported to rarely affect some families who are also prone to skin and gastrointestinal cancers.

What are the clinical features of Flegel's disease?

The lesions are small, reddish brown, 1–5 mm. scaly papules that appear most commonly on the upper surface of the feet and legs. removal of the scale reveals a bright red base, often with pinpoint hemorrhage. Rarely, the external ear lobes, arms, palms, soles, and mouths. mucous membrane they can be affected. The papules are usually not painful.

Flegel's disease


Flegel's disease


Flegel's disease


Flegel's disease

How is Flegel's disease diagnosed?

Flegel's disease is sometimes diagnosed clinically, especially if there is a family history of Flegel's disease. Otherwise, a biopsy can lead to a pathological diagnosis of Flegel's disease.

What treatment is available?

injuries are benign and are treated primarily for cosmetic reasons. Treatment of Flegel's disease includes:

  • Current 5% fluorouracil cream used for several months
  • Dermabrasion
  • Cryotherapy
  • Current retinoid
  • An oral retinoid such as acitretin or isotretinoin.